5-methyl-2-phenyl-4-Thiazolol synthesis
- Product Name:5-methyl-2-phenyl-4-Thiazolol
- CAS Number:70547-26-1
- Molecular formula:C10H9NOS
- Molecular Weight:191.25
Yield:70547-26-1 75%
Reaction Conditions:
with pyridine at 23 - 100; for 2 h;Inert atmosphere;
Steps:
4.1.2.6 General procedure (F). Preparation of 4-Hydroxy-5-methylthiazole
General procedure: Pyridine (0.005mol) was added to a mixture of thiolactic acid (0.02mol) and nitrile (0.0.2mol) at 23°C under argon. The reaction mixture was then heated at 100°C for 2h. After cooling, the precipitate was collected, washed with absolute ethanol, and recrystallized from methanol to afford the product.
References:
Khanfar, Mohammad A.;Reiner, David;Hagenow, Stefanie;Stark, Holger [Bioorganic and Medicinal Chemistry,2018,vol. 26,# 14,p. 4034 - 4046] Location in patent:supporting information
