5-(methylsulfonyl)-1H-indole synthesis
- Product Name:5-(methylsulfonyl)-1H-indole
- CAS Number:152879-73-7
- Molecular formula:C9H9NO2S
- Molecular Weight:195.24
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Yield:152879-73-7 100%
Reaction Conditions:
with manganese(IV) oxide in dichloromethane at 20;
Steps:
112.1
Example 112; 2-(3-Fluoro-phenyl)-pyrimidine-5-carboxylic acid (5-methanesulfonyl-indol-l-yl)-amide; Step 1 : A solution of 5-methanesulfonyl-indoline (4.11 mmol) and MnO2 (20.55 mmol) in DCM (20 mL) is stirred at rt overnight. The reaction mixture is filtered and the filtrate is concentrated in vacuo to afford 5 -methanesulfonyl- 1 H-indole (782 mg, 100%) as a solid. MS: 196 (M+H); 1H NMR (300 MHz, CDCl3): δ 3.09 (s, 3H), 6.71 (s, H), 7.39 (s, H), 7.53 (d, H), 7.74 (m, H), 8.30 (s, H), 8.66 (br, N-H).
References:
WO2008/121670,2008,A1 Location in patent:Page/Page column 129
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