5-MORPHOLIN-4-YLMETHYL-FURAN-2-CARBOXYLIC ACID synthesis
- Product Name:5-MORPHOLIN-4-YLMETHYL-FURAN-2-CARBOXYLIC ACID
- CAS Number:26095-36-3
- Molecular formula:C10H13NO4
- Molecular Weight:211.21
860477-83-4
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26095-36-3
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Yield:26095-36-3 94%
Reaction Conditions:
with water;sodium hydroxide in methanol at 40; for 10 h;
Steps:
33
The obtained compound 33g (260mg, 1.06mmol) was dissolved in methanol (10mL), sodium hydroxide solid (87mg, 2.17mmol) was added, 2 drops of water were added dropwise, and the mixture was stirred at 40°C for 10h. After the reaction was monitored by TLC, the concentration was added dropwise. Hydrochloric acid to the solution pH=4-6, the solvent was evaporated, the solid obtained was dissolved in a mixed solution of dichloromethane/methanol (dichloromethane: methanol=3:1), filtered with suction, and the filtrate was evaporated to remove the solvent to obtain compound 33h (shallow Brown solid, 220 mg, yield 94%).
References:
CN111763201,2020,A Location in patent:Paragraph 0220; 0024; 0230
2528-00-9
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26095-36-3
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$45.00/250mg