5-(Pentafluoroethyl)pyridine-2-carbonitrile synthesis
- Product Name:5-(Pentafluoroethyl)pyridine-2-carbonitrile
- CAS Number:1421951-81-6
- Molecular formula:C8H3F5N2
- Molecular Weight:222.11
557-21-1
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1421951-81-6
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Yield:1421951-81-6 4.19 g
Reaction Conditions:
with tetrakis(triphenylphosphine) palladium(0) in 1-methyl-pyrrolidin-2-one at 80; for 2.5 h;
Steps:
47.2 Production Example 47(2)
Production Example 47(2) A mixture of the half amount of 2-chloro-5- pentafluoroethyl pyridine obtained in Production Example 47(1), zinc (II) cyanide (14.4 g) , tetrakistriphenylphosphine palladium (2.42 g) and N-methyl pyrrolidone (84 ml) was heated to 80°C, and stirred for 2.5 hours. The reaction mixture was cooled to room temperature, and water and methyl-tert-butyl ether were poured thereto. The resulting precipitate was filtrated through celite (registered trademark) , and the residue was washed with methyl-tert-butyl ether. The filtrate was extracted with methyl-tert-butyl ether. The organic layer was dried over sodium sulfate, and concentrated under reduced pressure. The crude product was subjected to silica gel column chromatography to give 2-cyano-5-pentafluoroethyl pyridine .(4.19 g) . 2-cyano-5-pentafluoroethyl pyridine 1H-NMR (CDC13) δ : 8.97-8.96 (lH,m), 8.12-8.09 (lH,m), 7.90- 7.87 (lH,m)
References:
WO2013/18928,2013,A1 Location in patent:Paragraph 0389
748101-41-9
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118559-21-0
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1421951-81-6
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$109.00/100mg
69045-79-0
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1421951-81-6
8 suppliers
$109.00/100mg