5-Phenyl-1,3,4-oxadiazole-2-methanol synthesis
- Product Name:5-Phenyl-1,3,4-oxadiazole-2-methanol
- CAS Number:54014-02-7
- Molecular formula:C9H8N2O2
- Molecular Weight:176.17
16691-25-1
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54014-02-7
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$84.00/250mg
Yield:54014-02-7 80%
Reaction Conditions:
with sodium tetrahydroborate;calcium chloride in ethanol at 0 - 20; for 4 h;
Steps:
1.C Step C: Synthesis of (5-phenyl-1,3,4-oxadiazol-2-yl)methanol
Ethyl 5-phenyl-1,3,4-oxadiazole-2-carboxylate (2.71g, 12.42mmol)And calcium chloride (2.76g, 24.84mmol) suspended in ethanol (150mL),Add sodium borohydride (1.41g, 37.26mmol) at 0°C. After the addition,Move to room temperature and stir for 4 hours. Add water to quench the reaction (100mL),Ethyl acetate extraction (100mL x 2), the organic phase was washed with saturated brine (100mL x 3),It was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain 1.75 g of white solid, yield: 80%.
References:
CN112979629,2021,A Location in patent:Paragraph 0161; 0167-0168
613-94-5
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93-58-3
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54014-02-7
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611-73-4
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54014-02-7
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1013-23-6
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54014-02-7
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