5-phenyl-3-pyridin-2-yl-1,2,4-oxadiazole synthesis
- Product Name:5-phenyl-3-pyridin-2-yl-1,2,4-oxadiazole
- CAS Number:13389-61-2
- Molecular formula:C13H9N3O
- Molecular Weight:223.23
425619-08-5
1 suppliers
inquiry
13389-61-2
3 suppliers
inquiry
Yield:13389-61-2 203 mg
Reaction Conditions:
with sodium hydroxide in dimethyl sulfoxide at 20; for 2 h;
Steps:
General procedure for the synthesis of 1,2,4-oxadiazoles 4a-w
General procedure: To a solution of carboxylic acid 1 (1.1 mmol) in dry DMSO (0.5-1 mL) CDI (195 mg, 1.2 mmol) was added. The reaction mixture was stirred at room temperature for 30 min, then amidoxime 2 (1.0 mmol) was added. The reaction mixture was stirred at room temperature for another 18 h, then to the reaction mixture powdered NaOH (1.2 mmol) was added rapidly. The reaction mixture was stirred at room temperature for 2 h. Then the reaction mixture was diluted with cold water (30 mL). The resulting precipitate was filtered off, washed with cooled water (25 mL) and dried in air at 50 °C.
References:
Sharonova, Tatyana;Pankrat'eva, Vitalina;Savko, Polyna;Baykov, Sergey;Shetnev, Anton [Tetrahedron Letters,2018,vol. 59,# 29,p. 2824 - 2827] Location in patent:supporting information
1121-60-4
522 suppliers
$10.60/10gm:
13389-61-2
3 suppliers
inquiry