ChemicalBook CAS DataBase List 5-propylbenzene-1,3-diol

5-propylbenzene-1,3-diol synthesis

13synthesis methods

Product Name:5-propylbenzene-1,3-diol
CAS Number:500-49-2
Molecular formula:C9H12O2
Molecular Weight:152.19

In a 100 mL round bottom flask, open to the atmosphere was added the crude product Benzene, 1,3-dimethoxy-5-propyl (0.736 g, 4.08 mmol, 1.0 equiv.) and a 1:1 mixture of glacial acetic acid (20 mL, 349.7 mmol, 17.4 M) and hydrobromic acid (48% in H2O, 20 mL, 368.3 mmol, 18.4 M). The reaction mixture was refluxed at 125 °C for 3 hours while stirring, or until the starting material was consumed via TLC analysis. At this point, the reaction was allowed to cool to room temperature and quenched by the addition of DI H2O. The biphasic solution was added to a separatory funnel, wherein the organic portion was extracted Et2O (ca. 3x 20 mL). The organic layers were then combined, neutralized with a concentrated sodium bicarbonate solution (ca. 30 mL), washed with a saturated brine solution (ca. 50 mL), dried over MgSO4, filtered, and concentrated in vacuo to afford the final product without 5-Propyl-1,3-benzenediol (0.609 g, 99% yield) as a pale yellow oil.

41395-10-2
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500-49-2
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Yield:500-49-2 99%

Reaction Conditions:

with hydrogen bromide;acetic acid in water at 125; for 3 h;Inert atmosphere;

Steps:

5-propylbenzene-1,3-diol (19a).
In a 100 mL round bottom flask, open to the atmosphere was added the crude product SI-2 (0.736 g, 4.08 mmol, 1.0 equiv.) and a 1:1 mixture of glacial acetic acid (20 mL, 349.7 mmol, 17.4 M) and hydrobromic acid (48% in H2O, 20 mL, 368.3 mmol, 18.4 M). The reaction mixture was refluxed at 125 °C for 3 hours while stirring, or until the starting material was consumed via TLC analysis. At this point, the reaction was allowed to cool to room temperature and quenched by the addition of DI H2O. The biphasic solution was added to a separatory funnel, wherein the organic portion was extracted Et2O (ca. 3x 20 mL). The organic layers were then combined, neutralized with a concentrated sodium bicarbonate solution (ca. 30 mL), washed with a saturated brine solution (ca. 50 mL), dried over MgSO4, filtered, and concentrated in vacuo to afford the final product without purification (0.609 g, 99% yield) as a pale yellow oil.

References:

Golliher, Alexandra E.;Tenorio, Antonio J.;Dimauro, Nina O.;Mairata, Nicolas R.;Holguin, F. Omar;Maio, William [Tetrahedron Letters,2021,vol. 67,art. no. 152891] Location in patent:supporting information

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2-Hydroxy-4-oxo-6-propyl-2-cyclohexene-1-carboxylic Acid Methyl Ester

27871-91-6
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500-49-2
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References

1132-21-4 Synthesis

1132-21-4
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500-49-2
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$80.00/500mg

References

17213-57-9 Synthesis

17213-57-9
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500-49-2
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$80.00/500mg

References

7311-34-4
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$10.00/1g

500-49-2
93 suppliers
$80.00/500mg

References