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ChemicalBook CAS DataBase List 5-TRIFLUOROMETHYL-2-PYRIDINESULFONYL CHLORIDE

5-TRIFLUOROMETHYL-2-PYRIDINESULFONYL CHLORIDE synthesis

2synthesis methods
-

Yield:-

Steps:

21.5 21.5
21.5 Preparation of 5-trifluoromethyl-2-pyridylsulfonylchloride The pyridinethiol of Example 21.4 was converted to the corresponding sulfonyl chloride using the method of Fors, et al., J. Org. Chem. 63:7348 (1998). Briefly, the pyridinethiol (3.5 g) was suspended in 1M HCL (53 mL) and cooled in ice. Chlorine gas was bubbled into the tared reaction flask until 3 eq (4.2 g) had been added. The resulting white solid was dissolved in cold methylene chloride (25 mL) and extracted from the HCl solution. The aqueous layer was washed with an additional 12.5 mL of methylene chloride.

References:

Tularik Inc. US6200995, 2001, B1

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