1-(1-hydroxynaphthalen-2-yl)-3-Morpholin-4-ylpropane-1,3-dione synthesis
- Product Name:1-(1-hydroxynaphthalen-2-yl)-3-Morpholin-4-ylpropane-1,3-dione
- CAS Number:503469-16-7
- Molecular formula:C17H17NO4
- Molecular Weight:299.32
1696-20-4
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$6.00/10g
948-03-8
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$168.00/5g
503469-16-7
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$373.00/100mg
Yield:503469-16-7 78%
Reaction Conditions:
Stage #1: 4-acetylmorpholinewith lithium diisopropyl amide in tetrahydrofuran;hexane at -10; for 1.5 h;
Stage #2: 1-hydroxy-naphthalene-2-carboxylic acid methyl ester in tetrahydrofuran;hexane at 25; for 16 h;
References:
Griffin, Roger J.;Fontana, Gabriele;Golding, Bernard T.;Guiard, Sophie;Hardcastle, Ian R.;Leahy, Justin J. J.;Martin, Niall;Richardson, Caroline;Rigoreau, Laurent;Stockley, Martin;Smith, Graeme C. M. [Journal of Medicinal Chemistry,2005,vol. 48,# 2,p. 569 - 585]