2-Acrylamido-2-methyl-1-propanesulfonic acid sodium salt synthesis

Yield:-

Reaction Conditions:

with sodium hydroxide in water; pH=> 1 - > 5 at 30; for 2 h;

Steps:

11 Example 11: Preparation Protocol for the Sodium Salt of the Hydrated Crystalline Form of 2-acrylamido-2-methylpropane sulfonic acid
To a jacketed 2000-mL reactor equipped with a condenser, a pH meter and a stirrer, 500 grams of the hydrated crystalline form of acrylamido-2-methylpropane sulfonic acid from example 2 and 770 grams of water were added. The mixture had a pH of less than 1. (A solution of 50% concentration by weight sodium hydroxide was prepared in a dropping funnel. The caustic solution was added to the reaction mixture for 120 minutes. The temperature was controlled to be less than 30° C. During the sodium hydroxide addition, the pH remained under 5. 175 grams of 50% concentration by weight sodium hydroxide solution was added. The mixture obtained was a solution of the 2-acrylamido-2-methylpropane sulfonic acid sodium salt at a concentration of 35% by weight.

References:

S.P.C.M. SA;FAVERO, Cédrick;KIEFFER, Johann US2020/31765, 2020, A1 Location in patent:Paragraph 0241-0245

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