(alphaR)-alpha-Hydroxy-N-[2-(4-nitrophenyl)ethyl]benzeneacetamide synthesis
- Product Name:(alphaR)-alpha-Hydroxy-N-[2-(4-nitrophenyl)ethyl]benzeneacetamide
- CAS Number:521284-19-5
- Molecular formula:C16H16N2O4
- Molecular Weight:300.31
611-71-2
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$13.00/5g
29968-78-3
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$18.00/5g
521284-19-5
160 suppliers
$7.00/250mg
Yield:521284-19-5 93.7%
Reaction Conditions:
with benzotriazol-1-ol;N-[3-(N,N-dimethylamino)-propyl]-N'-ethyl-carbodiimide hydrochloride;triethylamine in N,N-dimethyl-formamide at 20; for 1 h;
Steps:
1 Example 1: Preparation of compound of formula (V)
200 g of the compound of formula (VII) and 286 g of compound of formula (VI) were added to 1.6 kg of N,N-dimethylformamide, and 132 g of triethylamine, 178 g of 1-hydroxybenzotriazole and 264 g of EDCI were added at room temperature. The reaction was stirred at room temperature for 1 h, 1.6 kg of purified water was added, stirred for 2 h for crystallization, filtered and dried to obtain 371 g of the compound of formula (V) with a yield of 93.7%.
References:
CN113880720,2022,A Location in patent:Paragraph 0038-0040
24954-67-4
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inquiry
54256-33-6
4 suppliers
inquiry
521284-19-5
160 suppliers
$7.00/250mg
24954-67-4
77 suppliers
inquiry
611-71-2
649 suppliers
$13.00/5g
521284-19-5
160 suppliers
$7.00/250mg
611-71-2
649 suppliers
$13.00/5g
521284-19-5
160 suppliers
$7.00/250mg