Ethyl 5-methoxy-1,2-dimethyl-4-nitroindole-3-carboxylate synthesis
- Product Name:Ethyl 5-methoxy-1,2-dimethyl-4-nitroindole-3-carboxylate
- CAS Number:52535-61-2
- Molecular formula:C14H16N2O5
- Molecular Weight:292.29
40963-98-2
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Yield:-
Reaction Conditions:
with nitric acid;acetic acid at 0 - 20; for 2 h;
Steps:
24B Synthesis of quinone 2
To a solution of 20 g (81 mmol, 1 eq.) ethyl 5-methoxy-1,2-dimethyl-1H-indole-3- carboxylate in acetic acid (200 mL), cooled to 0°C was added a mixture of nitric acid (4.6 mL) and acetic acid (20 mL). The mixture was then stirred at rt for 2 h. A yellow suspension was obtained which was poured on to an ice-water mixture and the crystals obtained were filteredoff and dried. Crude product was purified by flash chromatography to afford product as a yellow solid (14.0 g, 59.3%)
References:
WO2018/31662,2018,A1 Location in patent:Page/Page column 177; 178
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