4-Hydroxy-6-Methoxy-[1,5]naphthyridine-3- carboxylic Acid Ethyl Ester synthesis
- Product Name:4-Hydroxy-6-Methoxy-[1,5]naphthyridine-3- carboxylic Acid Ethyl Ester
- CAS Number:53241-92-2
- Molecular formula:C12H12N2O4
- Molecular Weight:248.23
![2-[(6-METHOXYPYRIDIN-3-YLAMINO)METHYLENE]MALONIC ACID DIETHYL ESTER](/CAS/GIF/53241-90-0.gif)
53241-90-0
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Yield:53241-92-2 73%
Reaction Conditions:
with diphenyl ether-biphenyl eutectic for 0.333333 h;Heating / reflux;
Steps:
1.b
Dowtherm A (Fluka, 500 mL) was brought to boiling (250 0C) in a 2 L 3-neck flask fitted with a still-head and a reflux condenser. 2-[(6-Methoxypyridin-3- ylamino)methylene]malonic acid diethyl ester (100 g, 0.34 mole) was added portion-wise over 5 min. The solution was heated at reflux for an additional 15 min, allowing some solvent to distil over. The resulting solution was cooled to room temperature and diluted with hexane (750 mL). The mixture was cooled in ice for 1 h, then the brown solid was filtered off, washed with hexane, and dried under vacuum to afford the title compound (61.72g, 73%).
References:
WO2006/81178,2006,A2 Location in patent:Page/Page column 18 WO2006/81289,2006,A2 Location in patent:Page/Page column 18
6628-77-9
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