Ethyl 2,2-difluoro-3-amino-propanoate hydrochloride synthesis
- Product Name:Ethyl 2,2-difluoro-3-amino-propanoate hydrochloride
- CAS Number:541547-37-9
- Molecular formula:C5H9F2NO2
- Molecular Weight:153.13
541547-36-8
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$122.00/100mg
541547-37-9
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$238.00/0.25G
Yield:-
Reaction Conditions:
with hydrogen;trifluoroacetic acid;palladium(II) hydroxide/carbon in ethanol at 20; under 3102.97 Torr;
Steps:
166
Compound 166: 4-(9-Cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9- tetrahydro-5H-pyrimido[4,5-b][l,4]diazepin-2-ylamino)-3-methoxy-N-(l- methylpiperidin-4-yl)benzamide; [0660] Ethyl 3-(dibenzylamino)-2,2-difluoropropanoate (24 Ig, 0.72 mol) was dissolved in EtOH (IL) and then 20% Pd(OH)2/C (24g) and trifluoroacetic acid (6OmL, 0.78 mol) were added. The vessel was repeatedly purged with hydrogen three times and then left under hydrogen (60 psi, 413 kP) and shaken overnight. The mixture was filtered through a pad of Celite , washed with ethanol and the filtrate was concentrated without heating to give 20Og of compound ethyl 3-amino-2,2-difluoropropanoate which contained a little bit of ethanol.
References:
WO2009/42711,2009,A1 Location in patent:Page/Page column 408-409
1403948-00-4
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541547-37-9
33 suppliers
$238.00/0.25G
111773-24-1
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$50.00/250mg
541547-37-9
33 suppliers
$238.00/0.25G