2-Thioxo-5-(4-methoxybenzylidene)thiazolidine-4-one synthesis

3synthesis methods

Product Name:2-Thioxo-5-(4-methoxybenzylidene)thiazolidine-4-one
CAS Number:5462-97-5
Molecular formula:C11H9NO2S2
Molecular Weight:251.32

141-84-4
248 suppliers
$8.00/5g

123-11-5 Synthesis

123-11-5
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$10.00/10g

2-Thioxo-5-(4-methoxybenzylidene)thiazolidine-4-one

5462-97-5
10 suppliers
$160.00/500mg

Yield:5462-97-5 93%

Reaction Conditions:

with thiourea;urea at 110; for 0.116667 h;Neat (no solvent);Knoevenagel condensation;

Steps:

General procedure for the synthesis of 5-arylidenethiazolidine-2,4-diones and 5-arylidene-2-thioxothiazolidin-4-ones:

General procedure: A mixture of aldehyde (1 mmol), 2,4-thiazolidinediones/2-thioxothiazolidin-4-ones (1 mmol) using 10 mol % urea/thiourea as catalyst was condensed at 110 °C on oil bath under solvent-free reaction conditions. After completion of the reaction as indicated by TLC, the crude product was cooled, washed with water (10 mL), filtered and recrystallization from ethanol: DMF to afford 3a-ab.

References:

Shah, Sakshi;Singh, Baldev [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 17,p. 5388 - 5391] Location in patent:experimental part

141-84-4
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$8.00/5g

2826-26-8
110 suppliers
$30.00/20mg

5462-97-5
10 suppliers
$160.00/500mg

References

141-84-4
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$8.00/5g

538-51-2 Synthesis

538-51-2
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$45.00/1g

Thiourea, N-[(4-methoxyphenyl)methylene]-

244032-72-2
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3806-42-6
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5462-97-5
10 suppliers
$160.00/500mg

References