1-BENZYL-5-METHYL-1H-[1,2,3]TRIAZOLE-4-CARBOXYLIC ACID synthesis
- Product Name:1-BENZYL-5-METHYL-1H-[1,2,3]TRIAZOLE-4-CARBOXYLIC ACID
- CAS Number:54698-60-1
- Molecular formula:C11H11N3O2
- Molecular Weight:217.22
133992-58-2
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$45.00/10mg
54698-60-1
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$58.00/100mg
Yield:54698-60-1 97.2%
Reaction Conditions:
Stage #1: 1-benzyl-5-methyl-1H-1,2,3-triazol-4-carboxylic acid ethyl esterwith lithium hydroxide monohydrate in tetrahydrofuran;water at 20; for 16 h;
Stage #2: with hydrogenchloride in water;
Steps:
2.H Synthesis of l-benzyl-5-methyl-lH-l, 2, 3-triazole-4-carboxylic acid (Int-H2)
[00127] To a stirring solution of compound Int-G2 (8.2 g, 33.4 mmol) in THF/H20 (82 mL/82 mL, 1 : 1) was added LiOH.H20 (4.2 g, 0.40mmol) at RT and stirred for 16 h. After completion of reaction (by TLC), the volatiles were evaporated under reduced pressure. The residue was acidified with aqueous 2N HCl and the precipitated solid was filtered and washed with water (25 mL), dried under reduced pressure to afford compound Int-H2 (7.0 g, 97.2%) as an off-white solid. H-NMR(H2): (400 MHz, DMSO-d6): δ 13.01 (br s, 1H), 7.40-7.32 (m, 5H), 5.63 (s, 2H), 2.45 (s, 3H). LCMS m/z: 218.3[M++1].
References:
WO2014/120800,2014,A1 Location in patent:Paragraph 00127; page 45
590-93-2
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622-79-7
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54698-60-1
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$58.00/100mg
622-79-7
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54698-60-1
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664351-09-1
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54698-60-1
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$58.00/100mg
100-39-0
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54698-60-1
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$58.00/100mg