ChemicalBook CAS DataBase List 4,4-dimethylisoquinoline-1,3(2H,4H)-dione(WXC08802)

4,4-dimethylisoquinoline-1,3(2H,4H)-dione(WXC08802) synthesis

2synthesis methods

Product Name:4,4-dimethylisoquinoline-1,3(2H,4H)-dione(WXC08802)
CAS Number:5488-36-8
Molecular formula:C11H11NO2
Molecular Weight:189.21

99911-10-1 Synthesis

2-(2-cyanopropan-2-yl)benzonitrile(WX191825)

99911-10-1
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4,4-dimethylisoquinoline-1,3(2H,4H)-dione(WXC08802)

5488-36-8
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Yield:5488-36-8 97.3%

Reaction Conditions:

with sulfuric acid at 20 - 60;Cooling;

Steps:

4.1 4.2. Synthesis of compound 20: The English name is: 4,4-dimethylisoquinoline-1,3(2H,4H)-dione;

Under cooling in an ice water bath, compound 19 (13.8 g, 0.081 mol) was added to H2SO4 (90%, 44 mL), stirred at room temperature for 2 days, and stirred at 60 °C overnight. The reaction solution was cooled to room temperature and then poured into stirred ice water, filtered, washed with water, and dried in vacuo to obtain off-white solid compound 20 (14.9 g, yield 97.3%).

References:

CN110950868,2020,A Location in patent:Paragraph 0140-0142; 0148-0152

4456-77-3 Synthesis

1,2,3,4-Tetrahydroisoquinoline-1,3-dione

4456-77-3
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5488-36-8
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References