(3β,20S)-4,4,20-Trimethyl-21-[[tris(isopropyll)silyl]oxy]-pregn-5-en-3-ol 3-Benzoate synthesis
- Product Name:(3β,20S)-4,4,20-Trimethyl-21-[[tris(isopropyll)silyl]oxy]-pregn-5-en-3-ol 3-Benzoate
- CAS Number:552302-70-2
- Molecular formula:C40H64O3Si
- Molecular Weight:621.02
![Pregn-5-en-3-ol, 4,4,20-trimethyl-21-[[tris(1-methylethyl)silyl]oxy]-, (3β,20S)- (9CI)](/CAS/20210305/GIF/462102-91-6.gif)
Yield:-
Reaction Conditions:
in pyridine;
Steps:
8.a (20S)-20-[(piperidin-1-yl)methyl]-4,4-dimethyl-5α-pregna-5,7-dien-3β-ol (Compound No. 14)
a) (20S)-4,4 dimethyl-20-[((triisopropylsilyl)oxy)methyl]-prena-5-en-3-ol benzoate 34.4 ml of benzoylchloride were added to a solution of 70 g crude (20S)-4,4-dimethyl-20-[((triisopropylsilyl)oxy)methyl]-pregna-5-en-3β-ol (Example 1c) (not purified by chromatography) in 670 mg pyridine at 0-3° C. The reaction mixture was stirred for 2 h at room temperature and poured into ice-water. The precipitate was filtered off, washed with water and recrystallized from acetone to give 42 g of (20S)-4,4-dimethyl-20-[((triisopropylsilyl)oxy)methyl]-pregna-5-en-3β-ol benzoate. 1H-NMR (CDCl3): δ=8.05 (2H, d); 7.56 (1H, t); 7.45 (2H, t); 5.60 (1H, t); 4.74 (1H, m); 3.68 (1H, dd); 3.36 (1H, m).
References:
US2002/188143,2002,A1
13154-24-0
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552302-70-2
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40736-33-2
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552302-70-2
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![(20S)-21-[[Tris(isopropyll)silyl]oxy]-20-methyl-pregn-4-en-3-one](/CAS/GIF/356063-47-3.gif)
356063-47-3
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552302-70-2
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$625.00/1mg
![Pregn-5-en-3-one, 4,4,20-trimethyl-21-[[tris(1-methylethyl)silyl]oxy]-, (20S)- (9CI)](/CAS/20210305/GIF/462102-90-5.gif)
462102-90-5
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552302-70-2
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$625.00/1mg