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ChemicalBook CAS DataBase List (1R,5S,6s)-3-Oxabicyclo[3.1.0]hexane-6-carboxylic acid

(1R,5S,6s)-3-Oxabicyclo[3.1.0]hexane-6-carboxylic acid synthesis

2synthesis methods
135637-81-9 Synthesis
(1R,5S,6S)-ETHYL 3-OXABICYCLO[3.1.0]HEXANE-6-CARBOXYLATE

135637-81-9
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Yield:55685-58-0 95%

Reaction Conditions:

with sodium hydroxide in ethanol;water at 20; for 18 h;Inert atmosphere;

References:

Seal, Jonathan T.;Atkinson, Stephen J.;Bamborough, Paul;Bassil, Anna;Chung, Chun-Wa;Foley, James;Gordon, Laurie;Grandi, Paola;Gray, James R. J.;Harrison, Lee A.;Kruger, Ryan G.;Matteo, Jeanne J.;McCabe, Michael T.;Messenger, Cassie;Mitchell, Darren;Phillipou, Alex;Preston, Alex;Prinjha, Rab K.;Rianjongdee, Francesco;Rioja, Inmaculada;Taylor, Simon;Wall, Ian D.;Watson, Robert J.;Woolven, James M.;Wyce, Anastasia;Zhang, Xi-Ping;Demont, Emmanuel H. [Journal of Medicinal Chemistry,2021,vol. 64,# 15,p. 10772 - 10805]