4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinazolin-7-ol synthesis
- Product Name:4-(4-Fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinazolin-7-ol
- CAS Number:574745-76-9
- Molecular formula:C18H14FN3O3
- Molecular Weight:339.32
574745-75-8
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574745-76-9
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$469.00/100mg
Yield:574745-76-9 100%
Reaction Conditions:
with 10% palladium hydroxide on charcoal;ammonium formate in N,N-dimethyl-formamide at 20; for 2 h;
Steps:
1 4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-6-methoxyquinazolin-7-ol
4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-7-(benzyloxy)-6-methoxyquinazoline (Compound 2, 0.46 g, 1.1 mmol) was dissolved in N,N-dimethylformamide (10 mL). Palladium hydroxide catalyst (250 mg, 10% on carbon) was added, followed by ammonium formate (0.67 g, 10.6 mmol). The reaction solution was stirred for 2 hours at room temperature. The catalyst was filtered through a CELITE pad, then the solution was evaporated, then dried in high vacuum overnight to generate Compound 3 as a brown solid (0.36 g, 100%) m/z: 340 (M+H, 100%) (positive ionization mode)
References:
US2014/235657,2014,A1 Location in patent:Paragraph 0327; 0328
![2-Propanone, 1-[2-fluoro-3-[[6-methoxy-7-(phenylmethoxy)-4-quinazolinyl]oxy]-6-nitrophenyl]-](/CAS/20210305/GIF/1022112-47-5.gif)
1022112-47-5
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574745-76-9
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288385-88-6
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574745-76-9
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162364-72-9
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574745-76-9
32 suppliers
$469.00/100mg