6-(2-bromoacetyl)nicotinonitrile synthesis

Yield:928649-94-9 80%

Reaction Conditions:

with pyridinium hydrobromide perbromide in tetrahydrofuran at 20;

Steps:

96

6-(2-Bromo-acetyl)-nicotinonitrile; Add pyridinium tribromide (9.2 g, 28.7 mmol) to a solution of 6-acetyl-nicotinonitrile (4.2 g, 28.7 mmol) in THF (200 mL) at room temperature. Filter off the solids and wash with minimal THF. Recrystalize the solid from EtOAc/hexane to obtain the desired intermediate as a light orange solid (5.2 g, 80%) that was used without further purification. MS (ES-) m/z: 223 (M-H)^".

References:

WO2007/28083,2007,A2 Location in patent:Page/Page column 142