6-(3,4-Dimethoxyphenyl)-picolinic acid synthesis
- Product Name:6-(3,4-Dimethoxyphenyl)-picolinic acid
- CAS Number:479225-16-6
- Molecular formula:C14H13NO4
- Molecular Weight:259.26
21190-87-4
395 suppliers
$10.00/5g
122775-35-3
331 suppliers
$5.00/1g
479225-16-6
7 suppliers
inquiry
Yield:-
Reaction Conditions:
with sodium hydrogencarbonate;tetrakis(triphenylphosphine) palladium(0) in water;toluene at 90; for 16 h;Suzuki Coupling;
Steps:
3.1
Step 1. Cis-6-(3,4-dimethoxyphenyl)-pyridim-2-carboxylic acidA mixture of 6-bromopicolinic acid (2.02 g, 10 mmol), 3,4-dimethoxyphenylboronic acid (1.8 g, 10.0 mmol), toluene (50 mL), NaHCO3 (saturated solution in water, 10 mL) and Pd(PPh3)4 (50 mg, 43 umol) is heated in a pressure tube at 90°C (oil bath temperature) for 16 h. The reaction mixture is cooled to room temperature and the aqueous layer separated. The organic layer is washed with NaHCO3 (saturated solution, 25 mL) and brine (3 x 50 mL). The solution is dried with MgSO4 and .the.solvent evaporated under reduced pressure to produce the crude title compound. LC/MS :_260_ (M+l).
References:
WO2006/15279,2006,A1 Location in patent:Page/Page column 46
1267666-27-2
0 suppliers
inquiry
479225-16-6
7 suppliers
inquiry