6,7-DIHYDRO-5H-CYCLOPENTA[B]PYRIDIN-2-OL synthesis
- Product Name:6,7-DIHYDRO-5H-CYCLOPENTA[B]PYRIDIN-2-OL
- CAS Number:88499-85-8
- Molecular formula:C8H9NO
- Molecular Weight:135.16
1590409-65-6
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88499-85-8
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Yield: 64%
Reaction Conditions:
with hydrogenchloride in water at 110; for 18 h;
Steps:
2 Step 2.
A solution of ethyl l-(3-amino-3-oxoprop-l-enyl)-2- oxocyclopentanecarboxylate (39 g, 173.33 mmol) in cone. HC1 (390 mL) was stirred in a sealed tube at 110 °C for 18 h. The solvent was removed and aq. NaHC03 solution was added to adjust pH to 8-9 at 0 °C. The resulting solid was filtered and washed with Et20 (2 x 100 mL) to afford 6,7-dihydro- l//-cyclopenta[h]pyridin-2(57 )-one (15 g, 64% yield) as an off white solid. MS (LCMS) 135.9 [M+H]+.
References:
ZENO ROYALTIES & MILESTONES, LLC;HUANG, Peter, Qinhua;BUNKER, Kevin, Duane;BOREN, Brant, Clayton;HEGDE, Sayee, Gajanan;LIU, Hui;UNNI, Aditya, Krishnan;ABRAHAM, Sunny;HOPKINS, Chad, Daniel;PALIWAL, Sunil WO2019/173082, 2019, A1 Location in patent:Paragraph 0156
1199941-88-2
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88499-85-8
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![2-OXO-2,5,6,7-TETRAHYDRO-1H-[1]PYRINDINE-3-CARBONITRILE](/CAS/GIF/108106-97-4.gif)
108106-97-4
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922-67-8
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88499-85-8
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1199941-88-2
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88499-85-8
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![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
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