6-BENZYLOXYINDOLE-3-ACETONITRILE synthesis
- Product Name:6-BENZYLOXYINDOLE-3-ACETONITRILE
- CAS Number:57765-24-9
- Molecular formula:C17H14N2O
- Molecular Weight:262.31
629662-36-8
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57765-24-9
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Yield:57765-24-9 86%
Reaction Conditions:
in ethanol;4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran;
Steps:
34.B PREPARATION OF 8-BENZYLOXY-3-(4-FLUOROBENZOYL)-1,1-DIMETHYL-1,2,3,6-TETRAHYDROAZEPINO[4,5-B]INDOLE-5-cARBOXYLIC ACID ETHYL ESTER
B. A mixture of (6-benzyloxy-1H-indol-3-ylmethyl)-trimethylammonium iodide (2.2 g, 5 mmol), sodium cyanide (500 mg, 10.2 mmol), and 95% EtOH (50 mL) was refluxed under nitrogen for 5 hours. The solvent was removed in vacuo, and the residue was taken in DCM, and washed with water, then dried with sodium sulfate, and evaporated in vacuo to afford a white solid, which was recrystallized from EtOH to give (6-benzyloxy-1H-indol-3-yl)-acetonitrile (1.25 g, 86%). MS (ES): 263 (MH+).
References:
US2005/54634,2005,A1
15903-94-3
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$14.00/1g
57765-24-9
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57765-22-7
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$125.09/10mg
57765-24-9
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40047-22-1
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$189.00/100mg
57765-24-9
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