6-BROMO-2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID synthesis
- Product Name:6-BROMO-2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID
- CAS Number:5463-29-6
- Molecular formula:C10H6BrNO3
- Molecular Weight:268.06
141-82-2
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$5.00/25g
87-48-9
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$10.00/5g
5463-29-6
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$55.00/250mg
Yield:5463-29-6 76%
Reaction Conditions:
with acetic acid at 130; for 16 h;
Steps:
B.20.1 Step 1
A mixture of R-3 (6.0 g, 26.55 mmol) and R-4 (8.2 g, 79.65 mmol) in acetic acid (25 mL) is stirred at 130oC for 16h. The reaction mixture is cooled and concentrated under reduced pressure to remove acetic acid. The residue is diluted with water (200 mL), neutralized with saturated aqueous NaHCO3to pH=7-8 and filtered. The filtrate is acidified with conc. aqueous HCl to pH=1-2, filtered and the solid is dried to afford I-1 (5.4 g, 76%).
References:
WO2021/50913,2021,A1 Location in patent:Paragraph 0304-0305
89446-19-5
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$31.00/100mg
5463-29-6
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$55.00/250mg
38418-24-5
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$167.00/100mg
5463-29-6
58 suppliers
$55.00/250mg
91-56-5
472 suppliers
$5.00/25g
5463-29-6
58 suppliers
$55.00/250mg