6-Bromo-3-nitro-4-quinolinol synthesis
- Product Name:6-Bromo-3-nitro-4-quinolinol
- CAS Number:853908-50-6
- Molecular formula:C9H5BrN2O3
- Molecular Weight:269.05
145369-94-4
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Yield:853908-50-6 64.5%
Reaction Conditions:
with nitric acid;propionic acid for 2 h;
Steps:
1.D Step D 3-Nitro-4-hydroxy-6-bromoquinoline (4a)
Synthesis of Compound 3a (29.0 g, 0.130 mol)Add to a 500 mL three-necked flask,Heat and stir until dissolved.Further, a mixture of nitric acid (40.95 g, 0.650 mol) and propionic acid (10 mL) was slowly added dropwise to the reaction flask.After the addition is completed, the reaction is further carried out for 2 hours.TLC detection [V (dichloromethane): V (methanol) = 15:1] The reaction was completed, cooled, filtered,The filter residue is added to the ice saturated sodium bicarbonate solution and stirred.Filtered,The residue is dry,The compound was obtained as a yellow solid (26.0 g, yield: 64.5%).
References:
CN108456165,2018,A Location in patent:Paragraph 0047; 0079-0080
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