6-Bromo-7-methyl-1,4-dioxaspiro[4.4]non-6-ene synthesis
- Product Name:6-Bromo-7-methyl-1,4-dioxaspiro[4.4]non-6-ene
- CAS Number:70156-97-7
- Molecular formula:C8H11BrO2
- Molecular Weight:219.08
80963-36-6
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Yield:70156-97-7 88%
Reaction Conditions:
with toluene-4-sulfonic acid;Triethyl orthoacetate in ethylene glycol at 20; for 3 h;Inert atmosphere;
Steps:
Synthesis of Intermediate K
To a 500 mL rbf, equipped with a stirrer bar, under an atmosphere of Argon was added 200 mL of triethyl orthoacetate (Aldrich), 7.8 g, 40 mmol, of Compound J and 38 mg, 0.2 mmol of para- toluenesulfonic acid. The reaction mixture was stirred at room temperature for 3 hours or until TLC analysis indicates the reaction has gone to completion and the product was distilled off under vacuum to give Compound K as a clear oil which solidified to a white solid on cooling in 88% yield >96% purity
References:
WO2014/145302,2014,A2 Location in patent:Page/Page column 34; 38
2758-18-1
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![Cyclopentanone, 3-methyl-3-[(4-methylphenyl)sulfonyl]-](/CAS/20210305/GIF/82222-80-8.gif)
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70156-97-7
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