6-bromo-N-cyclopropyl-1,3-benzothiazol-2-amine synthesis
- Product Name:6-bromo-N-cyclopropyl-1,3-benzothiazol-2-amine
- CAS Number:1177325-80-2
- Molecular formula:C10H9BrN2S
- Molecular Weight:269.16
408328-13-2
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Yield:1177325-80-2 68%
Reaction Conditions:
in 1,4-dioxane; for 6 h;Inert atmosphere;
Steps:
1046.3 Step 3: Synthesis of 6-bromo-N-cyclopropylbenzo[d]thiazol-2-amine
2,6-dibromobenzo[d]thiazole (1.0 g, 3.4 mmol) was suspended in 1,4-dioxane (10 ml), and added cyclopropylamine (3.6 ml, 51.0 mmol). The resultant mixture is stirred under nitrogen for 6 hours and cool to room temperature. On completion of reaction following a TLC examination, the reaction mixture was extracted with ethyl acetate and washed with brine. The solvent was removed. The crude product obtained was purified by flash chromatography (Hex:AcOEt 1:1) to afford 6-bromo-N-cyclopropylbenzo[d]thiazol-2-amine (0.630 mg, 68 % yield) as pale yellow solid. MS: 268.97 [M++1].
References:
WO2020/261294,2020,A1 Location in patent:Page/Page column 61-62
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