6-Chloro-2-(trifluoromethyl)nicotinonitrile synthesis
- Product Name:6-Chloro-2-(trifluoromethyl)nicotinonitrile
- CAS Number:1245913-20-5
- Molecular formula:C7H2ClF3N2
- Molecular Weight:206.55
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Yield: 37%
Reaction Conditions:
with tert.-butylhydroperoxide;bis-(((isopropyl)sulfinyl)oxy)zinc;zinc sulfinate in water;dimethyl sulfoxide at 20 - 50; for 12 h;regioselective reaction;
References:
O'Hara, Fionn;Blackmond, Donna G.;Baran, Phil S. [Journal of the American Chemical Society,2013,vol. 135,# 32,p. 12122 - 12134] Location in patent:supporting information