6-chlorothiazolo[4,5-c]pyridin-2-aMine synthesis
- Product Name:6-chlorothiazolo[4,5-c]pyridin-2-aMine
- CAS Number:1244058-73-8
- Molecular formula:C6H4ClN3S
- Molecular Weight:185.63
7321-93-9
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Yield:1244058-73-8 76%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane;water at 110; for 48 h;
Steps:
37 Example 37: Synthesis of (E)-9-(2-(6-chlorothiazolo[4,5-clpyridin-2-yl)hydrazono)-6,7,8,9- tetrahydrooxepino[3,2-blpyridine (98)
4,6-Dichloropyridin-3-amine (int-57) (1.5 g, 9.3 mmol) and potassium thiocyanate (2.69 g, 27.8 mmol) were dissolved in dioxane (30 mL) and concentrated aq. HC1 (0.1 mL) was added. The solution was stirred at 1 1() C for 2 days. Then, the solvent was removed under reduced pressure, and the residue was purified by column chromatography on silica gel using a mixture of petroleum ether and EtOAc (1:1) as eluent to give 6-chlorothiazolo[4,5-cjpyridin-2-arnine (int’58) (1.3 g, 76% yield) as a yellow solid. MS (ESI): mz 185.9 [M+H].
References:
WO2018/81612,2018,A1 Location in patent:Paragraph 0333
7321-93-9
163 suppliers
$20.00/100mg
1244058-73-8
11 suppliers
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