6-Cyano-2-(4-cyanophenyl)indole synthesis
- Product Name:6-Cyano-2-(4-cyanophenyl)indole
- CAS Number:28719-00-8
- Molecular formula:C16H9N3
- Molecular Weight:243.26
Yield:28719-00-8 91%
Reaction Conditions:
with chloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]copper(I);potassium acetate in N,N-dimethyl acetamide at 110; for 6 h;
Steps:
1.2; 2.2; 6.2 Step (2) Preparation of 6-cyano-2-(4'-cyanophenyl)indole
Under stirring at room temperature, the 6-cyanoindole (267.26g, 1.88mol) prepared in the previous step and 2L N,N-dimethylacetamide were sequentially added to the 5L reaction flask and stirred evenly.Then add 4-chlorobenzonitrile (258.63g, 1.88mol), potassium acetate (534.52g, 3.76mol), Chloro[1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]copper(I) (87mg, 0.18mmol), stir well.The reaction solution was heated to 110°C for 6 hours to complete the reaction.The reaction solution was cooled to room temperature, and most of the N,N-dimethylacetamide was recovered by distillation under reduced pressure.The residue was added to 2L ethyl acetate, washed twice with saturated brine, and spin-dried.The residue was recrystallized with toluene/tert-butyl methyl ether to obtain 416.19 g of brown-yellow solid powder product with a yield of 91%.
References:
CN113024437,2021,A Location in patent:Paragraph 0028; 0032-0034; 0041; 0045-0047; 0102; 0106-0108
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