(6-ethylpyridin-2-yl)methanol synthesis
- Product Name:(6-ethylpyridin-2-yl)methanol
- CAS Number:163658-33-1
- Molecular formula:C8H11NO
- Molecular Weight:137.18
688-99-3
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163658-33-1
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Yield:-
Steps:
Multi-step reaction with 4 steps
1: 5.5 g / Et3N / diethyl ether / 3 h
2: 1.) oxalyl chloride, DMSO, 2.) Et3N / 1.) CH2Cl2, 20 min, 2.) CH2Cl2, 20 min
3: 48 percent / H2, 48 percent HBF4 / Raney Ni / ethanol / 6 h / 760 Torr
4: 870 mg / LiAlH4 / tetrahydrofuran / 1 h / 0 °C
References:
Kempf, Dale J.;Sham, Hing L.;Marsh, Kennan C.;Flentge, Charles A.;Betebenner, David;Green, Brian E.;McDonald, Edith;Vasavanonda, Sudthida;Saldivar, Ayda;Wideburg, Norman E.;Kati, Warren M.;Ruiz, Lisa;Zhao, Chen;Fino, Lynnmarie;Patterson, Jean;Molla, Akhteruzzaman;Plattner, Jacob J.;Norbeck, Daniel W. [Journal of Medicinal Chemistry,1998,vol. 41,# 4,p. 602 - 617]
41337-78-4
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202817-14-9
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163658-33-1
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134370-37-9
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163658-33-1
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