6-Hydroxy-2-methylbenzoxazole synthesis
- Product Name:6-Hydroxy-2-methylbenzoxazole
- CAS Number:5078-07-9
- Molecular formula:C8H7NO2
- Molecular Weight:149.15
34781-86-7
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75-36-5
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5078-07-9
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Yield:-
Reaction Conditions:
with pyridinium p-toluenesulfonate;triethylamine in ethyl acetate
Steps:
34 2-Methyl-benzoxazol-6-ol
PREPARATION 34 2-Methyl-benzoxazol-6-ol 4-Aminoresorcinol hydrochloride (2.0 g, 12.4 mM), acetyl chloride (1.0 g, 12.6 mM), triethylamine (1.38 g, 13.6 mM) and pyridinium-p-toluenesulfonate (PPTS, 800 mg, 3.2 mM) were refluxed in xylenes (50 mL) for about 18 hours. Additional PPTS (300 mg) was added and the mixture was then refluxed about 48 hours. The reaction mixture was concentrated and the residue dissolved in ethyl acetate (200 mL) and washed with H2 O (3*150 mL). The combined aqueous layer was back extracted with ethyl acetate (200 mL) and the combined organic layers were dried over MgSO4. Filtration and concentration provided 1.36 g. Filtration through a silica gel column eluted with 10% methanol/methylene chloride provided an orange solid, 0.3 g; m.p., 94-96° C.
References:
Pfizer Inc US6130217, 2000, A
6134-79-8
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$57.50/250 mg
5078-07-9
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$60.00/250mg
111364-29-5
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5078-07-9
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$60.00/250mg
89-84-9
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5078-07-9
60 suppliers
$60.00/250mg
89-84-9
566 suppliers
$6.00/10g
6134-79-8
35 suppliers
$57.50/250 mg
5078-07-9
60 suppliers
$60.00/250mg