6-Hydroxy-2-quinolinecarboxylic acid synthesis
- Product Name:6-Hydroxy-2-quinolinecarboxylic acid
- CAS Number:75434-18-3
- Molecular formula:C10H7NO3
- Molecular Weight:189.17
429687-75-2
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75434-18-3
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$140.00/50mg
Yield:75434-18-3 99%
Reaction Conditions:
with lithium hydroxide monohydrate in tetrahydrofuran;lithium hydroxide monohydrate at 20; for 0.5 h;
Steps:
Step 3.
Lithium hydroxide (3.61 g, 151 mmol) was added to a mixtureof methyl 6-hydroxyquinoline-2-carboxylate 41 (10.2 g, 50.2 mmol),THF (200 mL) and water (70 mL) at ambient temperature. After 30 min,the THF was removed under reduced pressure, and the reaction mixturewas acidified with 1 M HCl to pH ~ 1. The precipitate was collected byfiltration and washed with water. The solid was dried for 18 h undervacuum at 50 C to give 6-hydroxyquinoline-2-carboxylic acid, 42 (9.40g, 99% yield).
References:
Patel, Meena V.;Peltier, Hillary M.;Matulenko, Mark A.;Koenig, John R.;C. Scanio, Marc J.;Gum, Rebecca J.;El-Kouhen, Odile F.;Fricano, Meagan M.;Lundgaard, Greta L.;Neelands, Torben;Zhang, Xu-Feng;Zhan, Cenchen;Pai, Madhavi;Ghoreishi-Haack, Nayereh;Hudzik, Thomas;Gintant, Gary;Martin, Ruth;McGaraughty, Steve;Xu, Jun;Bow, Daniel;Kalvass, John C.;Kym, Philip R.;DeGoey, David A.;Kort, Michael E. [Bioorganic and Medicinal Chemistry,2022,vol. 63,art. no. 116743]
75433-99-7
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75434-18-3
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$140.00/50mg
52313-34-5
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75434-18-3
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42454-06-8
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$8.00/1g
75434-18-3
36 suppliers
$140.00/50mg