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ChemicalBook CAS DataBase List 6'-HYDROXYMETHYL SIMVASTATIN
114883-29-3

6'-HYDROXYMETHYL SIMVASTATIN synthesis

4synthesis methods
125175-64-6 Synthesis
2,2-Dimethylbutanoic Acid [3R-[3a,5,5aa,6a(2R*,4R*),7a,9aS*]]-6-[2-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]tetrahydro-6-oxo-2H-pyran-2-yl]ethyl]-3,4,5,5a,6,7-hexahydro-7-methyl-2H-3,9a-methano-1-benzoxepin-5-yl Ester

125175-64-6
14 suppliers
$150.00/1mg

2H-Pyran-2-one, tetrahydro-4-hydroxy-6-[2-[5,6,7,8-tetrahydro-6-(hydroxymethyl)-2-methyl-1-naphthalenyl]ethyl]-, [4R-[4α,6β(R*)]]- (9CI)

139408-04-1
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Yield:114883-29-3 58%

Reaction Conditions:

with hydrogen fluoride in acetonitrile at 60;

References:

Lee;Hoffman;Holtz;Smith [Journal of Organic Chemistry,1992,vol. 57,# 7,p. 1966 - 1968]