6-iodo-1-hexyne synthesis
- Product Name:6-iodo-1-hexyne
- CAS Number:2468-56-6
- Molecular formula:C6H9I
- Molecular Weight:208.04
79496-61-0
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Yield: 72%
Reaction Conditions:
with sodium iodide in acetone at 20;Reflux;
Steps:
6-Iodohex-1-yne.
A mixture of hex-5-yn-1-yl methanesulfonate (26.6 g, 153 mmol) and sodiumiodide (25.3 g, 168 mmol) in acetone (350 mL) was stirred at room temperature overnight, thenrefluxed for 5 h. The mixture was concentrated to of the original volume, solids were filteredoff, and the filtrate was evaporated. The residue was purified by vacuum distillation (8 mm/Hg),affording 6-iodohex-1-yne as a colorless liquid; yield: 23 g (72%);
References:
Das, Viswanath;El Anwar, Suzan;Holub, Josef;Kugler, Michael;Nekvinda, Jan;Řezáčová, Pavlína;Šícha, Václav;Brynda, Jiří;Džubák, Petr;Dvořanová, Jana;Fábry, Milan;Grüner, Bohumír;Gurská, Soňa;Hajdúch, Marián;Havránek, Miroslav;Král, Vlastimil;Lišková, Barbora;Matějková, Stanislava;Medvedíková, Martina;Pospíšilová, Klára [European Journal of Medicinal Chemistry,2020,vol. 200] Location in patent:supporting information
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