6-METHYL-2-PHENYLQUINOXALINE synthesis
- Product Name:6-METHYL-2-PHENYLQUINOXALINE
- CAS Number:25187-18-2
- Molecular formula:C15H12N2
- Molecular Weight:220.27
Yield:25187-18-2 96%
Reaction Conditions:
with 1-methyl-3-(4-sulfobutyl)-1H-imidazol-3-ium hydrogensulfate at 70; for 1.06667 h;Green chemistry;
Steps:
General Procedure:
General procedure: A mixture of phenacyl bromide (1 mmol) and o-phenylenediamine (1.2mmol) in [MimC4SO3H]HSO4 (3 mL) was heated at 70oC for the appropriatetime (see Table 1). After completion of the reaction, as indicated by TLC, thereaction mixture was washed with diethylether (3x10mL). diluted with water(3 ml×10 ml). The combined ether extracts were concentrated in vacuo and theresulting product was directly charged onto a small silica gel column and elutedwith a mixture of ethyl acetate:n-hexane (0.5:9.5) to afford pure quinoxaline.The rest of the viscous ionic liquid was further washed with ether and recycledin subsequent runs. However, in the case of solids, the products were purifiedby recrystallization from appropriate solvents.The spectral and analytical data of all compounds are given below.
References:
Tejeswararao [Journal of the Chilean Chemical Society,2016,vol. 61,# 1,p. 2843 - 2845]
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