ChemicalBook CAS DataBase List 6-TRIFLUOROMETHOXY-PYRIDIN-3-YLAMINE

6-TRIFLUOROMETHOXY-PYRIDIN-3-YLAMINE synthesis

5synthesis methods

Product Name:6-TRIFLUOROMETHOXY-PYRIDIN-3-YLAMINE
CAS Number:135900-33-3
Molecular formula:C6H5F3N2O
Molecular Weight:178.11

2-chloro-6-(trifluoroMethoxy)pyridin-3-aMine

1221172-05-9
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135900-33-3
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Yield: 89.4%

Reaction Conditions:

with palladium 10% on activated carbon;ammonium formate in methanol at 55; for 16 h;

Steps:

55; 56; 57
[00537] A mixture of 81(2.00 g, 9.43 mmols, 1.0 eq), Pd/C (10%, 1.0 g), HCOONH4 (1.2 g, 18.9 mmols, 2.0 eq.) in MeOH (20 mL) was heated to 55 °C for 16 hours. The reaction mixture was cooled to room temperature, filtered through celite, and the filtrate was concentrated. The residue was partitioned between ethyl acetate (100 mL) and NaOH (4% in water, 30 mL). The organic layer were washed with brine, dried over Na2SO4, filtered, and concentrated to afford the desired product 82 (1.50 g, 8.38 mmols, 89.4%) as a yellow oil.

References:

ALPHARMAGEN, LLC;PUTMAN, David, G.;DASSE, Olivier;HOGENKAMP, Derk WO2016/144792, 2016, A1 Location in patent:Paragraph 00537

1221171-70-5
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135900-33-3
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References

1221172-02-6 Synthesis

6-chloro-2-(trifluoroMethoxy)-3-(triMethylsilyl)pyridine

1221172-02-6
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135900-33-3
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References

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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135900-33-3
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References

1000210-73-0
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135900-33-3
56 suppliers
$65.00/2.5mg

References