6-TRIFLUOROMETHOXY-PYRIDIN-3-YLAMINE synthesis
- Product Name:6-TRIFLUOROMETHOXY-PYRIDIN-3-YLAMINE
- CAS Number:135900-33-3
- Molecular formula:C6H5F3N2O
- Molecular Weight:178.11
1221172-05-9
14 suppliers
inquiry
135900-33-3
57 suppliers
$65.00/2.5mg
Yield: 89.4%
Reaction Conditions:
with palladium 10% on activated carbon;ammonium formate in methanol at 55; for 16 h;
Steps:
55; 56; 57
[00537] A mixture of 81(2.00 g, 9.43 mmols, 1.0 eq), Pd/C (10%, 1.0 g), HCOONH4 (1.2 g, 18.9 mmols, 2.0 eq.) in MeOH (20 mL) was heated to 55 °C for 16 hours. The reaction mixture was cooled to room temperature, filtered through celite, and the filtrate was concentrated. The residue was partitioned between ethyl acetate (100 mL) and NaOH (4% in water, 30 mL). The organic layer were washed with brine, dried over Na2SO4, filtered, and concentrated to afford the desired product 82 (1.50 g, 8.38 mmols, 89.4%) as a yellow oil.
References:
ALPHARMAGEN, LLC;PUTMAN, David, G.;DASSE, Olivier;HOGENKAMP, Derk WO2016/144792, 2016, A1 Location in patent:Paragraph 00537
1221171-70-5
86 suppliers
$71.00/250mg
135900-33-3
57 suppliers
$65.00/2.5mg
1221172-02-6
22 suppliers
inquiry
135900-33-3
57 suppliers
$65.00/2.5mg
![Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-](/CAS/20210305/GIF/1000210-73-0.gif)
1000210-73-0
0 suppliers
inquiry
135900-33-3
57 suppliers
$65.00/2.5mg
1000210-73-0
0 suppliers
inquiry
135900-33-3
57 suppliers
$65.00/2.5mg