1-(4-CHLOROPHENYL)-2,5-DIMETHYL-1H-PYRROLE-3-CARBOXYLIC ACID synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid; water / ethanol / 24 h / 80 °C
2: lithium hydroxide monohydrate / 1,4-dioxane; water / 24 h / 100 °C

References:

Mahy, William;Patel, Mikesh;Steadman, David;Woodward, Hannah L.;Atkinson, Benjamin N.;Svensson, Fredrik;Willis, Nicky J.;Flint, Alister;Papatheodorou, Dimitra;Zhao, Yuguang;Vecchia, Luca;Ruza, Reinis R.;Hillier, James;Frew, Sarah;Monaghan, Amy;Costa, Artur;Bictash, Magda;Walter, Magnus W.;Jones, E. Yvonne;Fish, Paul V. [Journal of Medicinal Chemistry,2020,vol. 63,# 17,p. 9464 - 9483]