9beta-(4-Chlorophenyl)-1,2,3,9beta-tetrahydro-5H-imidazo[2,1-a]isoindol-5-one synthesis

Yield:6038-49-9 73%

Reaction Conditions:

in toluene; for 5 h;Reflux;Dean-Stark;Solvent;

Steps:

Example preparation of compound 1h:

General procedure: A solution of 5h (1.0 g) in xylene (50 mL) wastreated with ethylenediamine (2.5 mL, 10 equiv) and heated to reflux for 5hours with a Dean-Stark condenser. The solvent was evaporated and theresidue purified by flash chromatography (1:1 EtOAc/hexane) to yield 6h(750 mg, 69%).

References:

Bond, Silas;Draffan, Alistair G.;Fenner, Jennifer E.;Lambert, John;Lim, Chin Yu;Lin, Bo;Luttick, Angela;Mitchell, Jeffrey P.;Morton, Craig J.;Nearn, Roland H.;Sanford, Vanessa;Stanislawski, Pauline C.;Tucker, Simon P. [Bioorganic and Medicinal Chemistry Letters,2015,vol. 25,# 4,p. 969 - 975]