N-[(1R,2R)-2-aMino-1,2-diphenylethyl]-BenzenesulfonaMide synthesis
1synthesis methods
- Product Name:N-[(1R,2R)-2-aMino-1,2-diphenylethyl]-BenzenesulfonaMide
- CAS Number:603996-85-6
- Molecular formula:C20H20N2O2S
- Molecular Weight:352.45
Yield:603996-85-6 70%
Reaction Conditions:
in dichloromethane;1,2-dichloro-ethane at 0; for 2 h;
Steps:
15.1
(1)According to the method of step (1) in Preparation 1,the difference is,Phenylsulfonyl chloride (20 mmol, available from J & K Technology, Inc. 112138)Instead of p-methylphenylsulfonyl chloride,And reacted at 0 ° C for 2h,Thereby obtaining 14 mmol of the chiral diamine represented by the formula (R, R) - (3-1-1-3) in a yield of 70%
References:
CN107286089,2017,A Location in patent:Paragraph 0176-0177