1,6-dihydro-4-hydroxy-2-methyl-6-oxonicotinonitrile synthesis
- Product Name:1,6-dihydro-4-hydroxy-2-methyl-6-oxonicotinonitrile
- CAS Number:64169-92-2
- Molecular formula:C7H6N2O2
- Molecular Weight:150.13
1118-61-2
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Yield:64169-92-2 540 mg
Reaction Conditions:
in chlorobenzene at 130; for 3 h;
Steps:
258.1 Step 1: 4-Hydroxy-2-methyl-6-oxo-1,6-dihydropyridine-3-carbonitrile
To a solution of bis(2,4,6-trichlorophenyl) malonate (3 g, 6.48 mmol) in chlorobenzene (30 mL) was added 3-aminobut-2-enenitrile (532.08 mg, 6.48 mmol) and the mixture was stirred at 130 °C for 3 hrs. The reaction mixture was then filtered and the solid was washed with toluene (5 mL) and petroleum ether (5 mL). The solid was dried to afford the title compound (540 mg) as a brown solid, which was used without further purification. MS-ESI (m/z) calcd for C7H7N2O2 [M+H]+: 151.0. Found 151.1.
References:
WO2021/7477,2021,A1 Location in patent:Page/Page column 408; 409
