Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
logo
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
My chemicalbook

Welcome back!

Structured search
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
645419-13-2

1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone synthesis

3synthesis methods
Ethanone, 1-(6'-nitrospiro[cyclopropane-1,3'-[3H]indol]-1'(2'H)-yl)-

645419-12-1
1 suppliers
inquiry

1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone

645419-13-2
32 suppliers
$45.00/10mg

-

Yield:645419-13-2 90%

Reaction Conditions:

with hydrogenchloride;Pd-C in methanol;ethanol;

Steps:

2 DC-2; 1-Acetyl-6-amino-1,2-dihydro-3-spiro-1'-cyclopropyl-1H-indole

DC-2; 1-Acetyl-6-amino-1,2-dihydro-3-spiro-1'-cyclopropyl-1H-indole A mixture of 1-acetyl-6-nitro-1,2-dihydro-3-spiro-1'-cyclopropyl-1H-indole (383 mg, 2 mmol) and Pd-C (10%, 100 mg) in EtOH (50 mL) was stirred at room temperature under H2 (1 atm) for 1.5 h. The catalyst was filtered off and the filtrate was concentrated under reduced pressure. The residue was treated with HCl/MeOH to give 1-acetyl-6-amino-1,2-dihydro-3-spiro-1'-cyclopropyl-1H-indole (DC-2) (300 mg, 90%) as a hydrochloride salt.

References:

US2011/98311,2011,A1 US2012/309758,2012,A1

1',2'-dihydrospiro[cyclopropane-1,3'-indole]

174-66-3
28 suppliers
$577.50/1g

1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone

645419-13-2
32 suppliers
$45.00/10mg

References
6'-Nitrospiro[cyclopropane-1,3'-indoline]

618446-19-8
14 suppliers
inquiry

1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone

645419-13-2
32 suppliers
$45.00/10mg

References

1-(6'-Aminospiro[cyclopropane-1,3'-indolin]-1'-yl)ethanone Related Search:

Indole