2,2,2-TRIFLUORO-1-(4-METHOXY-PHENYL)-ETHYLAMINE HYDROCHLORIDE synthesis

Yield:65686-77-3 72%

Reaction Conditions:

with hydrogenchloride;water in diethyl ether at 20; for 24 h;

Steps:

Typical procedure for the hydrolysis of substituted imines:

General procedure: Benzylidene-1-phenyl-2,2,2-trifluoroethylamine 4a (1 mmol, 0.2723 g) was first dissolved in 2 mL of diethyl ether and placed in a small vial. Hydrochloric acid (3 N, 5 mL) was slowly added after which the vial was closed and stirred for 24 h. Upon completion (as determined by TLC) the reaction mixture was added to ice water (10 mL) and then washed with diethyl ether (2 × 30 mL). The excess acid was removed by adding aqueous sodium hydroxide (3 N) till the solution turned slightly basic. The solution was the concentrated under vacuum to obtain the hydrochloride salt of 2,2,2-trifluoro-1-phenylethylamine 5a. All products were characterized by spectral analysis and by comparing the spectral data (for known compounds) with those of the authentic samples products. ^{(a), (b) and [10]}

References:

Prakash, G.K. Surya;Glinton, Kevin E.;Panja, Chiradeep;Gurung, Laxman;Battamack, Patrice T.;T?r?k, Béla;Mathew, Thomas;Olah, George A. [Tetrahedron Letters,2012,vol. 53,# 6,p. 607 - 611] Location in patent:experimental part