7-(benzyloxy)-2,3-dihydroinden-1-one synthesis
- Product Name:7-(benzyloxy)-2,3-dihydroinden-1-one
- CAS Number:125494-84-0
- Molecular formula:C16H14O2
- Molecular Weight:238.28
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Yield:-
Reaction Conditions:
with potassium carbonate in acetone;Reflux;
Steps:
13.2
Step 2: A mixture of S13-1 (10.36 g, 70 mmol), benzyl bromide (12 g, 70 mmol) and potassium carbonate (10.63 g, 77 mmol) in acetone (300 mL) was refluxed overnight. Then the reaction mixture was cooled to room temperature and filtered. The filtrate was concentrated and the residue was purified by column chromatography to afford S13-2. ‘H NMR (300 MHz, CDC13) ? 2.65 - 2.69 (m, 2H), 3.05 - 3.09 (m, 2H), 5.26 (s, 2H), 6.73 - 6.76 (d, J= 8.4 Hz, 1H), 6.96 -6.98 (d, J= 7.5 Hz, 1H), 7.24 -7.46 (m, 6H); LC-MS: (M+H) 239.
References:
WO2015/95261,2015,A1 Location in patent:Page/Page column 67
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