7-Bromo-2,2-dimethylchroman-4-one synthesis
- Product Name:7-Bromo-2,2-dimethylchroman-4-one
- CAS Number:130200-01-0
- Molecular formula:C11H11BrO2
- Molecular Weight:255.11
30186-18-6
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130200-01-0
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Yield:130200-01-0 60%
Reaction Conditions:
with pyrrolidine in toluene at 20; for 25 h;Reflux;
Steps:
5.1 Step 1. 7-bromo-2,2-dimethylchroman-4-one
1-(4-Bromo-2-hydroxyphenyl)ethan-1-one (5.0 g, 23.25 mmol) was dissolved in toluene (77 ml) and then acetone (8.6 ml, 116.25mmol) and pyrrolidine (1.91 ml, 23.25 mmol) were slowly added. The reaction mixture was stirred at room temperature for 1 hour, refluxed under stirring for 24 hours, and then concentrated under reduced pressure. The resulting residue was diluted with ethyl acetate, washed with a 6Nhydrochloric acid solution, a 2Nsodium hydroxide solution, and brine, and then concentrated under reduced pressure to give the titled compound as a brown solid. (3.6 g, Yield: 60%) The product was used in subsequent reaction without further purification.[489]1H-NMR (400MHz, CDCl3) δ 7.71(d, 1H), 7.15~7.10(m, 2H), 2.72(s, 2H), 1.46(s, 6H)
References:
WO2021/96241,2021,A1 Location in patent:Paragraph 487-489
591-20-8
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130200-01-0
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$31.00/100mg
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130200-01-0
34 suppliers
$31.00/100mg