7-Chlorobenzo[d]isothiazole synthesis

Yield:89583-90-4 54%

Reaction Conditions:

with sulfur;ammonium sulfate;potassium phosphate in dimethyl sulfoxide at 100; for 15 h;

Steps:

16 Example 15

Combine 2,3-dichlorobenzaldehyde (36.1 mg, 0.2 mmol), S80.1 mmol, 25.6 mg), potassium phosphate (0.3 mmol, 63.7 mg) and ammonium sulfate (0.2 mmol, 26.4 mg), DMSO (0.5 mL ), put it into a hot bath at a set temperature, and stir it magnetically. After the reaction was completed, cooled to room temperature, the reaction mixture was washed with saturated sodium carbonate solution, and extracted with CH2Cl2 (10 mL×3), then the organic layer was washed with saturated brine, and then the organic layer was dried with anhydrous sodium sulfate and filtered After that, the solution was concentrated under reduced pressure, and the resulting crude product was separated by thin-layer chromatography (TLC), and finally the pure product --7-chlorobenzo[d]isothiazole was obtained. White solid, the yield is 54%.

References:

CN113214182,2021,A Location in patent:Paragraph 0044-0045; 0061