7-chlorohept-1-yne synthesis
- Product Name:7-chlorohept-1-yne
- CAS Number:18804-36-9
- Molecular formula:C7H11Cl
- Molecular Weight:130.62
63478-76-2
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Yield:18804-36-9 83%
Reaction Conditions:
with pyridine;tin(ll) chloride in dichloromethane at 20; for 4.5 h;Cooling with ice;
Steps:
14.1 The first step: the synthesis of 7-chlorohept-1-yne (014B)
6-heptynol (1.35 g, 12.04 mmol) and pyridine (1.61 g, 20.46 mmol) were dissolved in dichloromethane (10 mL), and thionyl chloride (2.43 g, 20.46 mmol) was added dropwise with stirring in an ice-water bath, The mixture was stirred at room temperature for 4.5 hours, and the completion of the reaction was monitored by TLC.Dichloromethane (10 mL) was added, washed successively with water (20 mL×2) and saturated ammonium chloride (20 mL×2), the organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated to obtain a colorless liquid 7-chloroheptyl- 1-alkyne (1.3 g, 9.95 mmol, 83% yield).
References:
CN113943276,2022,A Location in patent:Paragraph 0397-0402
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