7-chlorohept-1-yne synthesis
- Product Name:7-chlorohept-1-yne
- CAS Number:18804-36-9
- Molecular formula:C7H11Cl
- Molecular Weight:130.62
63478-76-2
166 suppliers
$9.00/1g
18804-36-9
10 suppliers
inquiry
Yield:18804-36-9 83%
Reaction Conditions:
with pyridine;tin(ll) chloride in dichloromethane at 20; for 4.5 h;Cooling with ice;
Steps:
14.1 The first step: the synthesis of 7-chlorohept-1-yne (014B)
6-heptynol (1.35 g, 12.04 mmol) and pyridine (1.61 g, 20.46 mmol) were dissolved in dichloromethane (10 mL), and thionyl chloride (2.43 g, 20.46 mmol) was added dropwise with stirring in an ice-water bath, The mixture was stirred at room temperature for 4.5 hours, and the completion of the reaction was monitored by TLC.Dichloromethane (10 mL) was added, washed successively with water (20 mL×2) and saturated ammonium chloride (20 mL×2), the organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated to obtain a colorless liquid 7-chloroheptyl- 1-alkyne (1.3 g, 9.95 mmol, 83% yield).
References:
CN113943276,2022,A Location in patent:Paragraph 0397-0402
127016-34-6
0 suppliers
inquiry
18804-36-9
10 suppliers
inquiry
60274-60-4
88 suppliers
$31.00/5G
18804-36-9
10 suppliers
inquiry
30964-00-2
166 suppliers
$11.00/1g
18804-36-9
10 suppliers
inquiry
54512-75-3
367 suppliers
$14.00/5g
1066-26-8
97 suppliers
$48.00/50g
18804-36-9
10 suppliers
inquiry