ChemicalBook CAS DataBase List 7-DEAZA-7-IODO-2'-DEOXYGUANOSINE

7-DEAZA-7-IODO-2'-DEOXYGUANOSINE synthesis

6synthesis methods

Product Name:7-DEAZA-7-IODO-2'-DEOXYGUANOSINE
CAS Number:172163-62-1
Molecular formula:C11H13IN4O4
Molecular Weight:392.15

(2R,3S,5R)-5-(2-amino-5-iodo-4-methoxy-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2-(hydroxymethyl)tetrahydrofuran-3-ol

220036-88-4
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172163-62-1
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Yield:172163-62-1 98%

Reaction Conditions:

with sodium hydroxide for 4 h;Reflux;

Steps:

1.4 Example 1: Synthesis of 7-deaza-7-iodo-2'-deoxyguanosine dG-I

Step-IV: The compound dG1-D was placed in sodium hydroxide solution (2?) And refluxed for 4 hours. After cooling, 2N hydrochloric acid solution was added and the solution The liquid pH is 6. The mixture was washed with 100 ml of dichloromethane and methanol (V: V = 1: 1). The combined organic phases were concentrated to give 255 mg of a white solid, dG-I, in 98% yield. (1H-NMR of 16-1 is shown in Fig. 7)

References:

CN103601779,2016,B Location in patent:Paragraph 0041; 0052; 0053; 0054