7-Fluoro-6-nitro-1,2,3,4-tetrahydroisoquinoline synthesis
- Product Name:7-Fluoro-6-nitro-1,2,3,4-tetrahydroisoquinoline
- CAS Number:912878-83-2
- Molecular formula:C9H9FN2O2
- Molecular Weight:196.18
912846-65-2
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Yield:912878-83-2 450 mg
Reaction Conditions:
with hydrogenchloride in methanol;Inert atmosphere;Reflux;
Steps:
84.4 Step 4: 7-fluoro-6-nitro-1,2,3,4-tetrahydroisoquinoline
Step 4:
7-fluoro-6-nitro-1,2,3,4-tetrahydroisoquinoline
N-trifluoroacetyl-7-fluoro-6-nitro-1,2,3,4-tetrahydroisoquinoline (660mg, 2.3mmol) and methanol (10mL) were added to a 25ml reaction flask, and hydrochloric acid (2M, 6mL) was added under the protection of nitrogen.
The reaction solution was heated to reflux and reacted overnight, and then concentrated.
The residue was ground in diethyl ether, and the solid was collected by filtration to obtain the title compound (450mg).
The crude product was used directly for the subsequent reaction. (MS: [M+1] 197.1)
References:
EP3150592,2017,A1 Location in patent:Paragraph 0329; 0336; 0337
912846-64-1
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912878-83-2
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